🏈Game info: 49ers vs. Cardinals, Week 3 Preview

📅 Date/Time: Sunday, September 21, 2025 — Kickoff at 4:25 PM EDT / 1:25 PM PDT
🏟️ Location: Levi's Stadium, Santa Clara, California
📰 Posted: September 17, 2025

🏆 Game Overview

The San Francisco 49ers (2-0) host the Arizona Cardinals (2-0) in a highly anticipated NFC West showdown at Levi's Stadium. Both undefeated teams aim to maintain their perfect records in this early divisional clash. 🏈

📺 Broadcast Information

• 📺 Television:

• Nationwide: FOX (national broadcast) 📡

• Nationwide: NFL+, FOX Sports app, and streaming platforms carrying FOX games (e.g., FUBO, YouTube TV) 🌐

• San Francisco: KNBR 680 AM / 105.0 FM 📻

📊 Game Details

• 🎰 Spread & Over/Under: 49ers favored at -1.5; total points line at 45.5 (per BetMGM)

🔑 Key Storylines

🏆 San Francisco 49ers

The 49ers, fresh off a 26-21 win over the Saints, look to extend their unbeaten streak behind backup quarterback Mac Jones, who threw for 279 yards and 3 TDs in Week 2 replacing the injured Brock Purdy. 🏈 Running back Christian McCaffrey has been effective through the air with 15 receptions for 125 yards, despite ground game struggles. Wide receiver Jauan Jennings steps up in the passing game, but the team must manage injuries in the secondary. Defensively, the 49ers' unit remains one of the league's best, aiming to contain Arizona's offense. 💪

🐦 Arizona Cardinals

The Cardinals, coming off a 27-22 victory against the Panthers, seek their first win at Levi's Stadium since sweeping the 49ers last season. Quarterback Kyler Murray leads the charge, supported by running back James Conner and tight end Trey McBride. 🏈 Rookie wide receiver Marvin Harrison Jr. emerges as a key target, but the secondary has been plagued by injuries in Week 2, potentially vulnerable to San Francisco's passing attack. Arizona's defense looks to exploit the 49ers' quarterback situation. 🔒

🤕 Injury Report

• 🏆 49ers:

• Brock Purdy (QB, injury, out; Mac Jones starting) ❌

• Secondary players (multiple, injuries from Week 2, status uncertain) ❓

🔥 Why This Game Matters

For the 49ers, a win keeps their NFC West lead intact and tests their depth without key starters. 🏆 For the Cardinals, an upset victory on the road would solidify their early-season momentum and give them bragging rights in the division. 🐦 This matchup could set the tone for the NFC West race, with both teams vying for supremacy. 🎉

🔗 Where to Find More Information

For the latest updates, check official sources:

• NFL.com 🌐